TSPO imaging in stroke: from animal models to human subjects

Animal models of stroke: are they relevant to human disease?

Scientists have been modeling ischemic stroke in animals for over 150 years and have devised many ingenious methods to try to mimic the human condition. Nevertheless, the task remains formidable, even for the most talented scientist utilizing the most sophisticated technology. The challenge would be exceedingly difficult, even if we already understood all the pathophysiology underlying human st...

Nanomedicine for tuberculosis: Insights from animal models

Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...

Animal stroke models.

TSPO imaging in parkinsonian disorders

Microglial activation is a key aspect of the neuroinflammatory process in neurodegenerative disorders including idiopathic and atypical parkinsonian disorders. With positron emission tomography (PET) it has become possible to image this phenomenon in vivo and over the last years patterns of microglia activation corresponding with the known distribution of neuropathological changes in these diso...

Nanomedicine for tuberculosis: Insights from animal models

Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...